Alexander Bookbinder
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alexander.bookbinder@stonybrook.edu https://orcid.org/0009-0002-6897-7988
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Education
| Ph.D. | Biomedical Engineering, Medical Physics Track
Stony Brook University, Stony Brook, NY |
Aug 2024-present |
| B.Sc. | Nuclear Science and Engineering
Massachusetts Institute of Technology (MIT), Cambridge, MA |
Sep 2019-Jun 2023 |
Relevant Coursework
| Medical Physics | Radiation Biophysics, Radiation Physics, Radiation Oncology Physics, Magnetic Resonance |
| Biology | Fundamentals of Experimental Molecular Biology, Cell Biology, Biochemistry, Genetics, Metakaryotic Stem Cells in Carcinogenesis: Origins and Cures, Principles of Human Diseases and Aging, Organic Chemistry I, Principles and Practice of BME |
| Physics | Physics II: Electricity and Magnetism, Analog Electronics and Analog Instrumentation Design |
| Computation
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Intro to Modeling and Simulation, Intro to Computer Science Programming in Python, Intro to Computational Thinking and Data Science |
| Math | Probability and Random Variables, Differential Equations |
| Radiation | Introduction to Nuclear Engineering and Ionizing Radiation; Principles of Nuclear Radiation Measurement and Protection; Radiation Interactions, Control, and Measurement |
Research Experience
| Graduate Researcher, Digital Radiological Imaging Lab, Stony Brook University, Stony Brook, NY
Advisor/Supervisor: Wei Zhao, PhD. Project: Deep Learning-Based Image Processing for Breast Imaging · Used diffusion-based approach to improve breast image quality · Enhanced denoising without removing microcalficiations |
Aug 2024-present |
| Research Assistant, New York Proton Center (NYPC), New York, NY
Advisor/Supervisor: Minglei Kang, PhD. Project: Bragg Peak FLASH Planning in Eclipse · Imported, exported, modified Eclipse treatment plans with ESAPI scripting · Performed treatment planning in Eclipse · Wrote and modified DICOM-formatted range compensators, structures Project: In Vivo Dosimetry for Small Animal FLASH Experiments · Analyzed proton beam dose rates for 300+ mouse experiments |
Jul 2023-Aug 2024 |
| Undergraduate Researcher, Massachusetts General Hospital, Boston, MA
Advisor: Gregory Sharp, Ph.D. Project: DIR QA for Adaptive Proton Therapy · Used Plastimatch wrapped in Python to manipulate ITK and DICOM files · Assessed DIR quality with volumetric & intensity-based metrics · Assessed and visualized data with NumPy, SciPy, MatPlotLib, and Pandas |
Jun 2022-Jun 2023 |
| Undergraduate Researcher, MIT Nuclear Reactor Lab, Cambridge, MA
Advisor: Boris Khaykovich, Ph.D. & Gordon Kohse, Ph.D. Project: Neutron Tomography with Open-Source Software · Reconstructed structure from neutron image projections with MuhRec · Visualized results with ImageJ |
Jun 2020-Jan 2021 |
| Intern, Medstar Georgetown University Hospital, Washington, DC
Advisor: Dalong Pang, Ph.D. Project: Neutron Dose from Proton Therapy · Conducted simulations using MATLAB to wrap TOPAS extension for GEANT4 toolkit · Calculated and presented on neutron dose from proton therapy |
Jun 2018-Jul 2019 |
PUBLICATIONS
| Bookbinder, A.; Bobić, M.; Sharp, G.C.; Nenoff, L. An Operator-Independent Quality Assurance System for Automatically Generated Structures. Phys Med Biol. 2024;69(17):175003. doi:10.1088/1361-6560/ad6742 | 2024 |
| Bookbinder, A.; Selvaraj, B.; Zhao, X.; Yang, Y.; Bell, B.I.; Pennock, M.; Tsai, P.; Tomé, W.A.; Choi, J.I.; Guha, C.; Simone, C.B.; Lin, H.; Kang, M. Validation and Reproducibility of In Vivo Dosimetry for Pencil Beam Scanned FLASH Proton Treatment in Mice. Radiother. Oncol. 2024;198:110404. doi:10.1016/j.radonc.2024.110404 | 2024 |
| Bell, B.I.; Velten, C.; Pennock, M.; Kang, M.; Tanaka, K.E.; Selvaraj, B.; Bookbinder, A.; Koba, W.; Vercellino, J.; English, J.; Małachowska, B.; Pandey, S.; Duddempudi, P.K.; Yang, Y.; Shajahan, S.; Hasan, S.; Choi, J.I.; Simone, C.B.; Yang, W.-L.; Tomé, W.A.; Lin, H; Guha, C. Pencil beam scanned proton FLASH radiotherapy increases acute lethality. Int J Radiat Oncol Biol Phys. doi:10.1016/j.ijrobp.2024.09.006
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2024 |
| Bookbinder, A.; Krieger, M.; Lansonneur, P.; Magliari, A.; Zhao, X.; Choi, J.I.; Simone, C.B.; Lin, H.; Folkerts, M.; Kang, M. Implementation of a novel pencil beam scanning Bragg peak FLASH technique to a commercial treatment planning system. Submitted to Medical Physics. Aug 2024. | 2024 |
| Selvaraj, B.; Zhao, X.; Lin, H.; Shen, J.; Cheng, C.; Bookbinder, A.; Wu, H.; Zhai, H.; Choi, J.I.; Chhabra, A.M.; Hasan, S.; Simone, C.B.; Yamada, Y.; Kang, M. FLASH Stereotactic Body Radiation Therapy for Spine Tumors Using a Single-Energy Proton Pristine Bragg Peak Delivery Technique. Submitted to Radiother Oncol. | 2024 |
Presentations
| Bookbinder, A.; Krieger, M.; Magliari, A.; Lansonneur, P.; Lin, H.; Folkerts, M.; Kang, M. Exploring Options for Proton Flash Using Maximum Beam Energy. Poster with discussion accepted at FLASH Radiotherapy & Particle Therapy Conference, Rome, Italy, December 2024. | 2024 |
| Bookbinder, A.; Krieger, M.; Lansonneur, P.; Magliari, A.; Zhao, X.; Choi, J.I.; Simone, C.B.; Lin, H.; Folkerts, M.; Kang, M. Benchmarking the Performance of a Prototype Commercial TPS with a Novel Pencil Beam Scanning Bragg Peak Flash Technique and Scorecard-Based Optimization. Oral presentation accepted at the Particle Therapy Cooperative Group North America, New York, NY, November 2024. | 2024 |
| Bookbinder, A.; Selveraj, B.; Bell, B.I.; Pennock, M.; Tsai, P.; Choi, J.I.; Guha, C.; Simone, C.B.; Lin, H.; Kang, M. Validation and reproducibility of in vivo dosimetry for pencil beam scanned FLASH proton treatment in mice. Oral presentation accepted at the Particle Therapy Cooperative Group North America, New York, NY, November 2024. | 2024 |
| Bookbinder, A.; Krieger, M.; Lansonneur, P.; Magliari, A.; Zhao, X.; Choi, J.I.; Simone, C.B.; Lin, H.; Folkerts, M.; Kang, M. First Steps toward Implementing Pencil Beam Scanning Pristine Bragg Peak FLASH Planning into a Commercial Treatment Planning System. Poster delivered at American Society for Radiation Oncology Annual Meeting, Washington, DC, September 2024. | 2024 |
| Bookbinder, A.; Krieger, M.; Lansonneur, P.; Magliari, A.; Zhao, X.; Choi, J.I.; Simone, C.B.; Lin, H.; Folkerts, M.; Kang, M. Benchmarking the Performance of a Prototype Commercial TPS with a Novel Pencil Beam Scanning Bragg Peak Flash Technique and Scorecard-Based Optimization. Oral presentation delivered at the the American Association of Physicists in Medicine Annual Meeting, Los Angeles, CA, July 2024. | 2024 |
| Bookbinder, A.; Krieger, M.; Lansonneur, P.; Magliari, A.; Zhao, X.; Choi, J.I.; Simone, C.B.; Lin, H.; Folkerts, M.; Kang, M. Benchmarking the Performance of a Prototype Commercial TPS with a Novel Pencil Beam Scanning Bragg Peak Flash Technique and Scorecard-Based Optimization. Oral presentation delivered at the RAMPS Sal Vacirca Memorial Young Investigators Symposium, April 2024. | 2024 |
| Bookbinder, A.; Selveraj, B.; Bell, B.I.; Pennock, M.; Tsai, P.; Choi, J.I.; Guha, C.; Simone, C.B.; Lin, H.; Kang, M. Small Animal FLASH in vivo dosimetry: Dose and Dose Rate Reproducibility for 200 Mice. Oral presentation delivered at Radiosurgery Society Scientific Meeting, Chicago, IL, March 2024. | 2024 |
| Bookbinder, A.; Nenoff, L.; Bobić, M.; Sharp, G.C. Automated Contour Propagation Quality Assurance. Oral presentation delivered at the American Association of Physicists in Medicine Annual Meeting, Houston, TX, July 2023. | 2023 |
| Bookbinder, A.; Nenoff, L.; Bobić, M.; Sharp, G.C. Automated Contour Propagation Quality Assurance for Online Adaptive Proton Therapy. Oral presentation delivered at New England Chapter of the American Association of Physicists in Medicine Winter Meeting, Somerville, MA, March 2023. | 2023 |
Teaching Experience
| TA, Bioinstrumentation, Stony Brook University, Stony Brook, NY
· Instructed students in use of Lab View platform · Guided students through virtual instruments, analog electronic design |
Oct 2019-Jun 2023 |
Skills
| Computer | MATLAB, Python, SciPy, NumPy, Pandas, MatPlotLib, RayStation, Eclipse, ESAPI, DICOM |
| Laboratory | Radioactive sources, contamination/decontamination, radiation protection, spectroscopy, sterile technique, bacterial cultures and transformation, mutagenesis, protein/DNA purification, protein activity assays, Varian ProBeam beam delivery |
Professional & Work Experience
| Reactor Operator, MIT Nuclear Reactor Lab, Cambridge, MA
· Passed Nuclear Regulatory Commission licensing exam in Sep 2021 · Trained in radiological safety, dosimetry |
Oct 2019-Jun 2023 |
| Student Desk Worker, Random Hall, Cambridge, MA | Jun 2020-Jun 2023 |
Leadership Activities
| NYPC Physics Journal Club, Organizer
· Organized and ran biweekly physics journal club for NYPC Physics and Dosimetry departments |
Aug 2023-Aug 2024 |
| MIT Dormitory Council, Treasurer
· Oversaw events grants to dorms (~$25,000) · Prepared Dormitory Council Budget |
May 2022-May 2023 |
| MIT Association of Student Activities (ASA), President
· Oversaw >500 MIT student groups · Chaired weekly meetings, semesterly general body meetings |
Apr 2021-Apr 2023 |
| MIT ASA, Treasurer
· Oversaw events grants to student groups (~$175,000) · Chair of ASA treasury committee |
Apr 2020-Apr 2021 |
| Random Hall, President
· Organized and chaired internal dorm government meetings · Represented Random Hall to external student governments |
Jan 2022-Jan 2023 |
| Random Hall, Vice President
· Prepared Random Hall budget (~$20,000) |
Jan 2021-Jan 2022 |
| MIT Lecture Series Committee (LSC), Projection Director
· Oversaw projection committee for student-run movie theater · Responsible for training projectionists (~30 people trained) |
Jan 2020-Jan 2023 |
| Secular Society of MIT, Treasurer | Feb 2022-Jan 2023 |
| Secular Society of MIT, President | Sep 2019-Feb 2022 |
Download: CV 2024-11-12_sanitized