The goal is to provide a proper structure for the liver to regrow from the transplant as well as boosting growth of liver cells; creating a scaffold would be best for this. Electrospinning is the primary candidate for the fabrication of the scaffold, as it has been used for scaffold fabrication purposes, including liver cells. Electrospinning allows the scaffold to be porous, which facilitates cell growth and acts as a vehicle for drugs, proteins and enzymes.
The material used in the scaffold must be biocompatible and biodegradable, the scaffold must be able to reabsorb into the body so there is no need for an invasive removal of the device that would bring complications to the healing process. Biocompatibility is also vital as the device should not be rejected by the body and interrupt the liver’s healing process. So, a natural polymer should be considered for the scaffold, as most scaffolds often are.
Collagen is an effective and proven drug delivery vehicle, able to be chemically modified with drugs, enzymes, proteins, etc., to provide other functions, such as boosting cell regrowth from the base transplant [18, 19].
