Acute on-chronic liver failure (ACLF) is defined as a sudden loss of liver function accompanied with at least one additional organ failure (i.e. kidney, lungs, brain, etc.) in patients with pre-existing liver disease. As of 2018, ACLF has impacted 4.5 million Americans and has caused over 51,000 deaths in 2020 alone [1]. Common pre-existing conditions that are seen in patients with ACLF include bacterial infections (meningitis), hepatitis, and excessive alcohol or drug consumption [2]. Patients with ACLF experience symptoms such as cirrhosis (severe scarring of the liver due to liver damage), jaundice, and increased waste levels in the blood, such as bilirubin.