Peer-Reviewed Publications

Lee, K.H., Zhyvoloup, A., Ridgway, Z., Wong, A., Eldrid, C., Hannaberry, E., Thalassinos, K., Abedini, A. and Raleigh, D. P. Analysis of baboon IAPP provides insight into amyloidogenicity and cytotoxicity of human IAPP (2020) Biophys J. 118(5):1142-1151.

Abedini, A., Cao, P., Plesner, A., Zhang, J., He, M., Derk, J., Patil, S.A., Rosario, R., Lonier, J., Song, F., Koh, H., Li, H., Raleigh, D.P., and Schmidt, A.M. RAGE binds preamyloid IAPP intermediates and mediates pancreatic β-cell proteotoxicity (2018) J. Clin. Invest. 128(2): 682-698.

Abedini, A., Derk, J., and Schmidt, A.M. The receptor for advanced glycation endproducts is a mediator of toxicity by IAPP and other proteotoxic aggregates: Establishing and exploiting common ground for novel amyloidosis therapies (2018) Protein Science 27(7): 1166-1180.

Derk, J., Bermudez Hernandez, K., He, M., Koh, H., Abedini, A., Li, H., Fenyö, D. and Schmidt, A.M. Diaphanous 1 (DIAPH1) is highly expressed in the aged human medial temporal cortex and upregulated in myeloid cells during Alzheimer’s Disease (2018) J. Alzheimers Disease. (2018) 64(3): 995-1007.

Akter, R., Bower, R., Abedini, A., Schmidt, A.M., Hay D.L. and Raleigh, D.P. Amyloidogencity, cytotoxicity, and receptor activity of bovine Amylin: implications for xenobiotic transplantation and the design of nontoxic Amylin variants (2018) ACS Chem. Biol. 13(9): 2747-2757.

Ridgway, Z., Zhang, X., Wong, A.G., Abedini, A., Schmidt, A.M., Raleigh, D.P. Analysis of the role of the conserved disulfide in amyloid formation by human IAPP in homogenous and heterogenous environments (2018) Biochemistry. 57(21): 3065-3074.

Akter, R., Abedini, A., Ridgway, Z., Zhang, X., Kleinberg, J., Schmidt, A.M., Raleigh, D.P. Evolutionary adaptation and amyloid formation: does the reduced amyloidogenicity and cytotoxicity of ursine Amylin contribute to the metabolic adaption of bears and polar bears? (2017) Israel Journal of Chemistry. 57(7-8): 750-761.

Abedini, A., Plesner, A., Cao, P., Ridgway, Z., Zhang, J., Tu, L.H., Middleton, C.T., Chao, B., Sartori, D.J., Meng, F., Wang, H., Wong, A.G., Zanni, M.T., Verchere, C.B., Raleigh, D.P. and Schmidt, A.M. Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics (2016) eLIFE 5, pii: e12977.

Abedini, A., Cao P., Raleigh, D.P. Detection of helical intermediates during amyloid formation by intrinsically disordered polypeptides and proteins (2016) Methods Mol. Biol. 1345: 55-66.

Akter, R. Ping Cao, Noor, H., Ridgway, Z., Tu, T.-H., Wang, H., Wong,A. G., Zhang ,X., Abedini, A., Schmidt, A.M. and Raleigh, D.P. Islet amyloid polypeptide: structure, function and pathophysiology” (2016) Journal of Diabetes Research, Special Issue on: Recent Insight in Islet Amyloid Polypeptide Morphology, Structure, Membrane Interaction, and Toxicity in Type 2 Diabetes 2016:2798269.

Daffu, G., Shen, X., Senatus, L., Thiagarajan, D., Abedini, A., Hurtado Del Pozo, C., Rosario, R., Song, F., Friedman, R.A., Ramasamy, R., Schmidt, A.M. RAGE suppresses ABCG1-mediated macrophage cholesterol efflux in diabetes (2015) Diabetes. 64(12): 4046-4060.

Wang. H., Abedini, A., Ruzsicska, B.P., Raleigh, D.P. Rationally designed, non-toxic, non-amyloidogenic analogs of human islet amyloid polypeptide with improved solubility (2014) Biochemistry. 53(37): 5876-5884.

Cao, P., Abedini, A., Wang, H., Tu, L.H., Zhang, X., Schmidt, A.M., Raleigh, D.P. Islet amyloid polypeptide toxicity and membrane interactions (2013) Proc. Natl. Acad. Sci. USA 110(48): 19279-19284.

Abedini, A., Schmidt, A.M. Mechanisms of islet amyloidosis toxicity in type 2 diabetes (2013) FEBS Lett. 587(8): 1119-1127.

Cao, P., Abedini, A., Raleigh, D.P. Aggregation of islet amyloid polypeptide: from physical chemistry to cell biology (2013) Curr. Opin. Struct. Biol. 23(1): 82-89.

Cao, P., Marek, P., Noor, H., Patsalo, V., Tu, L.H., Wang, H., Abedini, A., Raleigh, D.P. Islet amyloid: From fundamental biophysics to mechanisms of cytotoxicity (2013) FEBS Lett. 587(8): 1106-1118.

Ladiwala, A.R., Bhattacharya, M., Perchiacca, J.M., Cao, P., Raleigh, D.P., Abedini, A., Schmidt, A.M., Varkey, J., Langen, R., Tessier, P.M. Rational design of potent domain antibody inhibitors of amyloid fibril assembly (2012) Proc. Natl. Acad. Sci. USA. 109(49): 19965-19970.

Cao, P., Tu, L.H., Abedini, A., Levsh, O., Akter, R., Patsalo, V., Schmidt, A.M., Raleigh, D.P. Sensitivity of amyloid formation by human islet amyloid polypeptide to mutations at residue 20.” (2012) J. Mol. Biol. 421(2-3): 282-295.

Meng, F., Abedini, A., Plesner, A., Verchere, B.C. and Raleigh, D.P. The flavanol (-)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP-induced toxicity (2010) Biochemistry. 49(37): 8127-8133.

Meng, F., Raleigh, D.P. and Abedini, A. Combination of kinetically selected inhibitors in trans leads to highly effective inhibition of amyloid formation (2010) J. Am. Chem. Soc. 132(41):v14340-14342.

Meng, F., Abedini, A., Plesner, A., Middleton, C.T., Potter, K.J., Zanni, M.T., Verchere, B.C. and Raleigh, D.P. The sulfated triphenyl methane derivative acid fuchsin is a potent inhibitor of amyloid formation by human islet amyloid polypeptide and protects against the toxic effects of amyloid formation (2010) J. Mol. Biol. 400(3):v555-566.

Potter, K., Abedini, A., Merek, P., Driscoll, M., Verchere, B.C. and Raleigh, D.P. Islet amyloid deposition limits the viability of human islet grafts but not porcine islet cell grants (2010) Proc. Natl. Acad. Sci. USA. 107(9): 4305-4310. Joint first authors

Cao, P., Meng, F., Abedini, A. and Raleigh, D.P. The ability of rodent islet amyloid polypeptide to inhibit amyloid formation by human islet amyloid polypeptide has important implications for the mechanism of amyloid formation and the design of inhibitors (2010) Biochemistry. 49(5): 872-81.

Abedini, A. and Raleigh, D.P. A critical assessment of the role of helical intermediates in amyloid fibril formation (2009) Protein Engineering, Design and Selection. 22(8): 453-459.

Abedini, A. and Raleigh, D.P. A role for helical intermediates in amyloid formation by natively unfolded polypeptides (2009) Physical Biology. 6(1) article ID 015005.

Potter, K., Abedini, A., Butterworth, S., Driscoll, M., Marek, P., Korbutt, G., Fraser, P., Verchere, C.B., and Raleigh, D.P. Lack of amyloidogenicity of pig Islet Amyloid Polypeptide may contribute to improved function and survival of pig islet xenografts (2008) J. Investigative Med. 56: 134-135.

Abedini, A. and Raleigh, D.P. Protein Misfolding: Amyloid Formation (2008) Wiley Encyclopedia of Chemical Biology. John Wiley and Sons.

Abedini, A., Meng, F. and Raleigh, D.P. A single point mutation converts highly amyloidogenic human islet amyloid polypeptide into a potent inhibitor of fibrillization (2007) J. Am. Chem. Soc. 129(37): 11300-11301.

Meng, F., Abedini, A., Song, B. and Raleigh, D.P. Amyloid formation by proIAPP processing intermediates: Examination of the role of protein-heparan sulfate interactions and implications for islet amyloid formation in type 2 diabetes (2007) Biochemistry. 46(43): 12091-12099.

Marek, P., Abedini, A., Song, B., Kanungo, M., Johnson, M.E., Gupta, R., Zaman, W., Wong, S.S. and Raleigh, D.P. Aromatic interactions are not required for amyloid formation by islet amyloid polypeptide but do influence the rate of fibril formation and fibril morphology (2007) Biochemistry. 46(11): 3255-3261.

Abedini, A., Tracz, S.M., Cho, J.H. and Raleigh, D.P. Characterization of the heparin binding site in the N-terminus of human pro-islet amyloid polypeptide: Implications for amyloid formation (2006) Biochemistry. 45(30): 9228-9237. Joint first authors

Abedini, A., Singh, G. and Raleigh, D.P. Recovery and purification of highly aggregation-prone disulfide-containing peptides: Application to islet amyloid polypeptide (2006) Anal. Biochem. 351(2), 181-186.

Abedini, A. and Raleigh, D.P. Destabilization of human IAPP amyloid fibrils by proline mutations outside of the putative amyloidogenic domain: Is there a critical amyloidogenic domain in human IAPP? (2006) J. Mol. Bio. 355(2): 274-281.

Abedini, A. and Raleigh, D.P. The role of His-18 in amyloid formation by human islet amyloid polypeptide (2005) Biochemistry. 44(49): 16284-16291.

Abedini, A. and Raleigh, D.P. Incorporation of pseudoproline derivatives allows the facile synthesis of human IAPP; a highly amyloidogenic and aggregation-prone polypeptide (2005) Organic Letters. 7(4): 693-696.

Tracz, S.M., Abedini, A., Driscoll, M. and Raleigh, D.P. The role of aromatic interactions in amyloid formation by polypeptides: Analysis of peptides derived from human amylin (2004) Biochemistry. 43(50): 15901-15908. Joint first authors

Book Chapters & Commentaries

Abedini, A. and Raleigh, D.R. Islet Amyloid Polypeptide (2009) In: Protein Misfolding Diseases: Current and Emerging Principles and Therapies. Edited by Dobson, C. M., Kelly, J. W. and Ramirez-Alvarado, M. Published by John Wiley and Sons.

Abedini, A., Gupta, R., Marek, P., Meng, F., Tracz, S., Taskent, H. and Raleigh, D.P. Post-Translational Modifications and Amyloid Formation.” (2009) In: Protein Misfolding Diseases: Current and Emerging Principles and Therapies. Edited by Dobson, C. M., Kelly, J. W. and Ramirez-Alvarado, M. Published by John Wiley and Sons.

Abedini, A. and Shoelson, S.E. STAMPing out insulin resistance? (2007) Immunology and Cell Biology. 85(6): 399-400.