I am currently working in Dr. Congwu Du’s laboratory at Stony Brook University developing and using cutting edge optical imaging systems such as laser speckle imaging, multispectral optical intrinsic signal imaging, and needle lens imaging. We use laser speckle imaging to evaluate the blood flow within the vasculature of the brain. We use multispectral optical intrinsic signal imaging to observe vasculature hemodynamics. We used needle lens imaging for deep brain imaging.  The mission of the lab is to improve the temporal and spatial resolution as well as the penetration depth of optical imaging systems to the limits of physics.

We also use laser doppler flowmetry (LDF) and  electroencephalogram (EEG) to study hemodynamic low frequency oscillations (LFOs). We examined the coupling of regional hemodynamic LFOs to neuronal activity in a resting brain. Our method involved the used of instantaneous-frequency (IF) analysis to detect regional LFOs of cerebral blood flow (CBF) along with local-field potential (LFP) changes of neurons in resting state to study neurovascular coupling. CBF and LFP were simultaneously acquired using laser Doppler flowmetry (LDF) and electroencephalography in the rat’s somatosensory cortex with high temporal resolution.