Lab Manager and Research Technician
Ph.D. Candidate, Genetics Program
I am broadly interested in cell cycle regulation of morphogenetic behavior. Specifically, I am currently focused on optimization of a live cell cycle state biosensor for use in C. elegans and other research organisms. I am also interested in how cell cycle state regulation impinges upon morphogenetic behaviors, such as C. elegans anchor cell invasion into the vulval epithelium.
Ph.D. Student, Genetics Program
My research interests lie in the field of Genetic Epidemiology; I am particularly interested in exploring the evolution and epigenetic regulation of genes that contribute to human morbidity. Currently, I am investigating the interactions among transcription factors in C. elegans that are known to regulate cell invasion, a behavior relevant to cancer metastasis.
Ph.D. Candidate and Turner Fellow, Genetics Program
I am broadly interested in trying to understand how chromatin state interfaces with regulation of cell invasive behavior. I am using C. elegans anchor cell invasion to identify the suite of chromatin modifiers that regulate invasion, with the hopes of identifying new therapeutic targets to limit the lethality associated with invasive pathologies, such as cancer metastasis.
M.D./Ph.D. Student, Genetics Program
Cell migration is important for proper embryological formation and development. The disruption or inappropriate activation of this cell behavior is often observed in conjunction with basement membrane invasion during cancer metastasis. My research will focus on establishing C. elegans SM cell migration and differentiation as a parallel model to anchor cell invasion into the vulval epithelium. By studying SM development with an eye toward the anchor cell model, I hope to more precisely understand traits unique to cell migration vs invasion.
Ph.D. Student, Molecular and Cellular Biology Program
My research focuses on the role of the cell cycle in cellular invasion, a biological process required for cancer metastasis. I am interested in exploring the link between cell cycle arrest and invasion, considering a new class of anti-cancer drugs (CDK4/6 inhibitors) target cell cycle arrest. I will use zebrafish and cell culture to perform this research in collaboration with Dr. Ben Martin’s lab.
Postdoctoral Fellow (jointly working with the Matus and Martin labs)
My work focuses on understanding how membrane trafficking events, such as endocytosis and exocytosis, mediate AC invasion. Specifically, I am interested in how endocytic compartments mobilize during AC invasion. Currently, I am investigating how the effector protein of the small GTPase, RAB-10, functions in AC invasion using both genetic and cell biological approaches.
Master’s Student, Biochemistry and Cell Biology Program
I am interested in investigating the evolution of the extracellular cues that mediate cell invasive behavior. Specifically, I am exploring the relationship and conservation of netrin signaling and the unknown vulval cue that spatially and temporally regulate the ability of the nematode anchor cell to breach the basement membrane using C. elegans and a related nematode, O. tipulae.
Rebecca C. Adikes, Ph.D.
I am currently investigating algal cell migration and invasion in the spotted salamander embryo. The work is a collaborative effort with Dr. Ryan Kerney, Dr. Solange Dumel, and Dr. John Burns. I am also investigating the role of cell invasion and migration during development of C. elegans.
M.D./Ph.D. Student, Molecular and Cellular Pharmacology Program
I have developed a keen interest in understanding the molecular and cellular mechanisms underlying invasion and metastasis, both hallmarks of cancer. In particular, I have developed an interest in learning more about the cell cycle requirements of metastatic cancer cells and their microenvironment. I am also interested in cancer cell nuclear dynamics during invasion events. Presently, I am investigating the effects of clinically approved cell cycle inhibitors on anchor cell (AC) invasion, which is an important step in the development of the C. elegans reproductive tract.
Undergraduate Student, Wesleyan University Class of 2019
I am interested in building new tools to study gene regulation during C. elegans anchor cell invasion using CRISPR/Cas9 genome engineering.
Matus Lab Alumni
R. Antonio Herrera, Ph.D.
Yee Man Li
High School Students: