Yi-Xian Qin, Ph.D.
Professor
From 1993- Present
Dr. Qin’s research is focused on the physical mechanisms involved in the control of tissue growth, healing, and homeostasis, especially bone adaptation and regeneration influenced by mechanical environment, as well as how these mechanisms can be utilized in the treatment and prevention of disease and injury and bone tissue engineering. His research is also focused on the development of non-invasive scanning acoustic diagnostic system for tissue quality, and therapeutic ultrasound. The goal of this project is to develop a new technology, which will lead to a better understanding of the progressive adaptation of bone loss in aging populations and microgravity environment. The technology will be used for assessing musculoskeletal complications such as osteoporosis and accelerate fracture healing.

Wei Lin, Ph.D.
Associate Professor
1997 – Present
Dr. Lin’s research focuses on the embedded systems and high performance computing technologies in biomedical applications. Research projects have covered a vast range from the wearable wireless infant monitor for the prevention of sudden infant death syndrome to ultrasound scanning imaging device for the assessment of bone properties.
Dr. Lin’s lab has adopted the latest technologies in embedded system design and established own platforms for the medical device prototyping to facilitate the transition of intellectual properties from bench side to bed side.

 Minyi Hu, Ph.D.
Postdoctoral Research Associate
August 2008 – Present
Dr. Minyi Hu has extensive experiences in research areas of bone biomechanics and cellular response to mechanical signals, with highlighted expertise in animal models, cell culture, histology, cell-based biochemical assays, cell signaling, microscopy and medical imaging, etc. The goal of her Ph.D. research was to design and develop novel therapeutic treatments for bone regeneration in osteoporotic rats to prevent the risk of fracture. Her current research focuses on biomechanical modulation on bone cell signaling. She also collaborates with internal and external lab teams to develop experimental research on hard and soft tissue regeneration, tissue engineering and mechanotransduction. Based on her research efforts, Dr. Hu has a proven track record of journal publications and conference presentations, and has been honored with numerous national and international awards. Besides research, Dr. Hu is also highly active in professional services as an invited lecturer in the Dept. of Physiology and Biophysics at SBU, reviewer for several scientific journals, ICMRS committee member and webmaster, judge for science and engineering fairs, and board member of SBU postdoc working group, etc.

Dongye Zhang, M.S.
Ph.D. Student
2011 – Present
Dongye a senior PhD graduate student working at Dr. Qin’s Orthopedic Research Lab at Stony Brook University. My research interest covers new therapeutic and diagnostic approaches for treatment and characterization of the disease of osteopenia and osteoporosis, which affects more than 200 million people worldwide and costs thousands of millions of dollar each year. We developed and adopted severe osteoporosis model where mechanical unloading simulated by hindlimb suspension and post-menopause condition caused by removal of ovary are combined. Scl-Ab, an anabolic therapeutic antibody developed for the treatment of osteoporosis by Amgen has been a research interest since sclerostin inhibition has been proved to be an attractive cure for the disease. We have the expertise in animal studies and various analytical method for the analysis and characterization of bone qualities both in vivo and in vitro, e.g. micro-computed tomography, MTS mechanical testing system, osteomeasure-assisted histomorphometry and nano-indentation.

Zhihua Gan, M.S.
Ph.D. Student
2014 – Present
Zhihua Gan is a Ph.D. candidate from Department of Electrical and Computer Engineering at Stony Brook University. She is currently working in Orthopaedic Bioengineering research laboratory as a research assistant. She also cooperates with Nanoscale Circuits and Systems (NanoCAS) Laboratory for research projects.
Her research interests include noise and power efficiency issues for integrated circuits (ICs) with an application to both analog and high-performance synchronous systems. She is also interested in software based flexible ultrasound transducer design as well as the low intensity ultrasound treatment oriented design for both transducer and control circuits.

Jian Jiao, M.S.
Ph.D. Student
2014 – Present
Jian had been working in orthopaedic industry, which is Naton Medical Group, as a project manager for three years from 2011 to 2014 before joining in the lab as a Ph.D student. Prior to that, Jian got an MSc degree in Biomedical Engineering at Institute of Medical Science and Technology in University of Dundee, UK. He has been working on some fascinating ultrasound projects since he started to work as a project research assistant, such as designing and testing of novel broadband transducers, fabrication of flexible ultrasound tomography devices, and micro-mechanotransduction with acoustic radiation force.
Jian’s research interest focuses on diagnostic and therapeutic ultrasound on bone, bone and implant mechanics, and bone mechanotransduction. Jian’s research motivation always comes from the clinical problems at the ‘bed’ and he tries hard to solve them at the ‘bench’ before returning to the ‘bed’. Besides research, Jian also likes travelling, swimming, and photography.

Xiaofei Li, M.S.
Ph.D. Student
2014 – Present
Xiaofei Li holds a master degree of biomedical engineering from Beihang University, and is currently a doctoral graduate student in Orthopeadic Bioengineering Research Laboratory. Her research interests are related to the application of ultrasound and Micro-CT to noninvasively diagnose musculoskeletal diseases, such as osteoarthritis and osteoporosis. During her graduate studies in Beihang University, her research project was to observe sGAG content in articular cartilage based on contrast agent Micro-CT and QUS, and she had several papers published on connective tissue research, ICBEB, ICMIPE, and EMBS conference. At present, she involves in a project mainly focused on applying super wideband TRS transducer (0.3MHz to 7MHz) to scan bone and tissue samples to evaluate ultrasound parameters in different frequencies.

Chaudhry Hassan 
Ph.D Student, M.Sc
2015 – Present
Currently, I am working on finite element analysis of human knee. For this purpose, I am developing a porous media based finite element model of human femur, knee, and tibia. My research interest includes finite element analysis of human hard tissues particularly knee and spine (lumbar), bone quantitative and qualitative analysis, whiplash associated disorder, and EEG brain activity.
Over the years, I have been involved in several biomedical projects which I successfully completed. Prior to joining Stony Brook University, I obtained M.Sc. in Biomedical Sciences & Engineering from Koç University, Turkey, and B.S. in Electrical Engineering from School of Science & Engineering, LUMS, Pakistan.

Fengyu Hao, M.D.
Visiting Scholar
2015 – Present
Fengyu Hao works at hospital of Stomatology, China medical university in Shenyang, China. Her major is prosthodontics and dental materials and her research interests include biological properties of bone grafts and implant material in vitro and in vivo. Now she is an exchange visitor in Dr. Qin’s Orthopedic Research Lab at Stony Brook University. Her research work is focused on the mechanism of effect of ultrasound stimulation osteoblasts and mMSC cells, and how the ultrasonic improve healing of bone fracture in vivo.

Guoxian Feng, M.D.
Labortary Technician
2005 – Present

 

 

 

 

 

 

Alyssa Tuthill, M.S.
Laboratory Manager
2008 – Present