Shigellosis or Bacillary Dysentery is a common cause of gastro-enteritis worldwide and can cause bloody diarrhea (called dysentery). It is an infectious disease caused by a group of bacteria called Shigella. Most who are infected with Shigella develop diarrhea, along with fever, and stomach cramps starting a day or two after they are exposed to the bacteria. Very recent past (Sept. 2015) statistics reported that 150 cases of Shigella infection was confirmed in Kansas City, USA. A scientific study was conducted to evaluate the effect of Mr. Mahendra Kumar Trivedi’s inherent biofield energy treatment on Shigella flexneri with respect to antimicrobial sensitivity, enzymatic activities, and biotyping. Mr. Trivedi’s unique biofield energy treatment is also popularized as The Trivedi Effect^®. The outcomes of this study has been already published in a reputed peer-reviewed International journal entitled “Air & Water Borne Diseases”. The antimicrobial susceptibility of S. flexneri showed 35% alteration in the biofield energy treated group as compared to control. Moreover, the minimum inhibitory concentration (MIC) value of biofield treated S. flexneri also showed significant (46.88%) alteration in biofield treated group as compared to control.  It was observed that overall 24.24% biochemical reactions were altered with respect to control. Moreover, biotype number was changed in the biofield energy treated group with identification of new organism i.e. Edwardsiella tarda (biotype number: 4001 5042) as compared to untreated strain of Shigella species (biotype number 4001 0000). Based on the changes of biochemical reaction pattern and biotyping of S. flexneri it is concluded that Mr. Trivedi’s biofield treatment could be applied as an alternative therapeutic approach to alter the sensitivity pattern of antimicrobials in near future.